Å‹ß‚̋ƐÑ

2017

Sunami H., Shimizu Y., Denda J., Yokota I., Yoshizawa T., Uechi Y., Nakasone H., Igarashi Y., Kishimoto H., Matsushita M.
Modulation of surface stiffness and cell patterning on polymer films using micropatterns.
Journal of Biomedical Materials Research: Part B - Applied Biomaterials 2017 May;doi:10.1002/jbm.b.33905. [Epub ahead of print]

Yuyama K., Igarashi Y.
Exosomes as carriers of Alzheimerfs amyloid-beta.
Frontiers in Neuroscience, in press.

Takao Sanaki T., Kasai-Yamamoto E., Yoshioka T., Sakai S., Yuyama K., Fujiwara T., Numata Y,. Igarashi Y.
Direct involvement of arachidonic acid in the development of ear edema via TRPV3.
Journal of Oleo Science, in press.

Wakabayashi M., Yoshioka T., Higashino K., Numata Y., Igarashi Y., Kihara A.
Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
J Dermatol Sci., 2017 Mar;85(3):186-196.

Saito S., Murai U., Usuki S., Yoshida M., Hammam M.A.S., MItsutake S., Yuyama K., Igarashi Y., Monde K.
Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction.
Eur. J. Org. Chem. 2017 Feb;6:1045-1051.

Sakamoto H., Yoshida T., Sanaki T., Shigaki S., Morita H., Oyama M., Mitsui M., Tanaka Y., Nakano T., Mitsutake S., Igarashi Y., Takemoto H.
Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
Biochem. Biophys. Res. Commun. 2017 Jan;482(2):202-207.

2016

Sekiguchi H., Suzuki T., Sakai S., Takahashi K., Hayashida S., Sutoh K., Usumi K., Katsumata Y., Igarashi Y.
A Study of Safety and Skin Improvment Effect of Beverage Containing Extracted Glucosylceramide form Tamogitake (Pleurotus cornucopiae var. citrinopileatus).
Trace Nutrients Research 2016;33:21-30.

Taniguchi M., Tasaki T., Ninomiya H., Ueda Y., Kuremoto K., Mitsutake S., Igarashi Y., Okazaki T., Takegami T.
Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus.
Scientific Reports 2016 Nov;6:37829.

Sugimoto M., Shimizu Y., Zhao S., Ukon N., Nishijima K., Wakabayashi M., Yoshioka T., Higashino K., Numata Y., Okuda T., Tamaki N., Hanamatsu H., Igarashi Y., Kuge Y.
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice.
BBA - Molecular and Cell Biology of Lipids 2016 Aug;1861(8 Pt A):688-702.

Mikami D., Sakai S., Sasaki S., Igarashi Y.
Effects of Asterias amurensis-derived sphingoid bases on the de novo ceramide synthesis in cultured normal human epidermal keratinocytes.
Journal of Oleo Science 2016 Aug;65(8):671-680.

Sugimoto M., Wakabayashi M., Shimizu Y., Yoshioka T., Higashino K., Numata Y., Okuda T., Zhao S., Sakai S., Igarashi Y., Kuge Y.
Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice.
PLoS One 2016 Mar;11(3):e0152191.

Usuki S., Tamura N., Sakai S., Tamura T., Mukai K., Igarashi Y.
Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action.
Biochemistry and Biophysics Reports 2016 Mar;5:160-167.

Yuyama K., Igarashi Y.
Physiological and Pathological Roles of Exosomes in the Nervous System.
Biomolecular Concepts 2016 Feb;7(1):53-68.

Gowda BS., Usuki S., Mostafa H., Murai Y., Igarashi Y., Monde K.
Highly Efficient Preparation of Sphingoid Bases from Glucosylceramides by Chemoenzymatic Method.
J. LIpid Res. 2016 Feb;57(2):325-331.

Suzuki M., Cao K., Kato S., Komizu Y., Mizutani N., Tanaka K., Arima C., Tai MC., Yanagisawa K., Togawa N., Shiraishi T., Usami N., Taniguchi T., Fukui T., Yokoi K., Wakahara K., Hasegawa Y., Mizutani Y., Igarashi Y., Inokuchi J., Iwaki S., Fujii S., Satou A., Matsumoto Y., Ueoka R., Tamiya-Koizumi K., Murate T., Nakamura M., Kyogashima M., Takahashi T.
Targeting CERS6-dependent Metastasis-prone Phenotype in Lung Cancer Cells.
J. Clin. Invest. 2016 Jan;126(1):254-265.

2015

Furukawa J., Sakai S., Yokota I., Okada K., Hanamatsu H., Kobayashi T., Yoshida Y., Higashino K., Tamura T., Igarashi Y., Shinohara Y.
Quantitative glycosphingolipid-glycome analysis of human whole serum based on an endoglycoceramidase digestion and glycoblotting method.
J. Lipid Res. 2015 Dec;56(12):2399-2407.

Sugimoto M., Shimizu Y., Yoshioka T., Wakabayashi M., Tanaka Y., Higashino K., Numata Y., Sakai S., Kihara A., Igarashi Y., Kuge Y.
Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains.
BBA - Molecular and Cell Biology of Lipids 2015 Dec;1851(12):1554-1565.

Yamagami K., Yamamoto T., Sakai S., Mioka T., Sano T., Igarashi Y., Tanaka K.
Inositol depletion restores vesicle transport in yeast phospholipid flippase mutant.
PloS One 2015 Mar;10(3):e0120108.

Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T, Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., Igarashi Y.
A potential function for neuronal exosomes: sequestering intracerebral amyloid-ƒÀ peptide.
FEBS Letters 2015 Jan;589(1):84-88.

2014

Hanamatsu H., Ohnishi S., Sakai S., Yuyama K., Mitsutake S., Takeda H., Hashino S., Igarashi Y.
Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults.
Nutrition and Diabetes 2014 Oct 20;4:e141.

Yuyama K., Sun H., Sakai S., Mitsutake S., Okada M., Tahara H., Furukawa JI., Fujitani N., Shinohara Y., Igarashi Y.
Decreased Amyloid-ƒÀ Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice.
J. Biol. Chem. 2014 Aug 29;289(35):24488-24498.

Sunami H., Yokota I., Igarashi Y.
Estimation of the angles migrating cells turn on three-dimensional micro-patterned scaffolds by live cell imaging with an inverted microscope.
e-Journal of Surface Science and Nanotechnology 2014;Vol.12:289-298.

Yuyama K., Mitsutake S., Igarashi Y.
Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease.
BBA - Molecular and Cell Biology of Lipids 2014 May;1841(5):793-798.

2013

Sunami H., Yokota I., Igarashi Y.
Influence of the pattern size of micropatterned scaffolds on cell morphology, proliferation,migration and F-actin expression.
Biomater. Sci. First published online 2013 Nov 28.

Mizutani S., Sun H., Ohno Y., Sassa T., Wakashima T., Obara M., Yuyama K., Kihara A., Igarashi Y.
Cooperative Synthesis of Ultra Long-chain Fatty Acid and Ceramide during Keratinocyte Differentiation.
Plos one 2013 Jun 27;8(6):e67317.

Mitsutake S., Igarashi Y.
Sphingolipids in lipid microdomain and obesity.
Vitamin and Hormones 2013 Feb 11;91 Obesity:271-294.

Hara-Yokoyama M., Terasawa K., Ichinose S., Watanabe A., Katarzyna A., Podyma-Inoue KA., Akiyoshi K., Igarashi Y., Yanagishita M.
Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.
Bioorganic & Medicinal Chemistry Letter 2013 Apr 1;23(7):2220-2224.

Murakami I., Mitsutake S., Kobayashi N., Matsuda J., Suzuki A., Shigyo T., Igarashi Y.
Oral administration of phytosphingosine improves high-fat diet-induced glucose intolerance.
Bioscience, Biotechnology, and Biochemistry 2013;77(1):194-197.

2012

Taniguchi M., Kitatani K., Kondo T., Nishimura M.H., Asano S., Hayashi A., Mitsutake S., Igarashi Y., Umehara H., Hiroyuki T., Kigawa J., Okazaki T.
Regulation of autophagy and its associated cell death by sphingolipid rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway.
Journal of Biological Chemistry 2012 Nov 16;287(47):39898-39910.

Zama K., Mitsutake S., Watanabe K., Okazaki T., Igarashi Y.
A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate.
Chemistry and Physics of Lipids 2012 Oct;165(7):760-768.

Shirakura Y., Kikuchi K., Matsumura K., Mukai K., Mitsutake S., Igarashi Y.
4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin.
Lipids in Health and Disease 2012 Aug 31;11(1):108.

Asano S., Kitatani K., Taniguchi M., Hashimoto M.,Zama K., Mitsutake S., Igarashi Y., Takeya M., Hayash A., Umehara H., Okazaki T.
Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway.
Molecular and Cell Biology 2012 Aug;32(16):3242-3252.

Mitsutake S., Date T., Yokota H., Sugiura M., Kohama T., Igarashi Y.
Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.
FEBS Letters 2012 May 7;586(9):1300-1305.

Yuyama K., Sun H., Mitsutake S., Igarashi Y.
Sphingolipid-modulated exosome secretion promotes the clearance of amyloid-beta by microglia.
J. Biol. Chem. 2012 Mar 30;287(14):10977-10989. Epub 2012 Feb 2.

Fujii Y., Ohtake H., Ono N., Hara T., Sakurai T., Takahashi S., Takayama T., Fukasawa Y., Shiozawa F., Tsukahara N., Hirayama T., Igarashi Y., Goitsuka R.
Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P.
BBA, molecular and cell biology of lipid. 2012 Apr ;Volume 1821 Issue 4:600-606.

Fujii Y., Ueda Y., Ohtake H., Ono N., Takayama T., Nakazawa K., Igarashi Y., Goitsuka R.
Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis.
Biochem Biophys Res Commun. 2012 Mar 23;419(4):754-760. Epub 2012 Feb 24.

Fujii Y., Hirayama T., Ohtake H., Ono N., Inoue T., Sakurai T., Takayama T., Matsumoto K., Tsukahara N., Hidano S., Harima N., Nakazawa K., Igarashi Y., Goitsuka R.
Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities.
J Immunol. 2012 Jan 1;188(1):206-215. Epub 2011 Nov 30.

2011

Fujitani N., Takegawa Y., Ishibashi Y., Araki K., Furukawa JI., Mitsutake S., Igarashi Y., Ito M., Shinohara Y.
Qualitative and Quantitative Cellular Glycomics of Glycosphingolipids Based on Rhodococcal EGCase -Assisted Glycan Cleavage, Glycoblotting-Assisted Sample Preparation and MALDI-TOF/TOF MS Analysis.
J Biol Chem. 2011 Dec 2;286(48):41669-41679. Epub 2011 Sep 30.

Shakor AB., Taniguchi M., Kitatani K., Hashimoto M., Asano S., Hayashi A., Nomura K., Bielawski J., Bielawska A., Watanabe K., Kobayashi T., Igarashi Y., Umehara H., Takeya H., Okazaki T.
SMS1-generatedsphingomyelin plays an important role in transferrin trafficking and cell proliferation.
J. Biol. Chem. 2011 Oct 14;286(41):36053-36062. Epub 2011 Aug 19.

Murakami I., Wakasa Y., Yamashita S., Kurihara T., Zama K., Kobayashi N., Mizutani Y., Mitsutake S., Shigyo T., Igarashi Y.
Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Lipids in Health and Disease. 2011 Aug 24;10:150.

Mitsutake S., Zama K., Yokota H., Yoshida T., Tanaka M., Mitsui M., Ikawa M., Okabe M., Tanaka Y., Yamashita T., Takemoto H., Okazaki T., Watanabe K., Igarashi Y.
Dynamics modification of sphingomyelin in lipid microdomains control development of obesity, fatty liver, and type 2 diabetes.
J. Biol. Chem. 2011 Aug 12;286(32):28544-28555. Epub 2011 Jun 13.

2010

Okuda A.,1 Naganuma T., Ohno Y., Abe K., Yamagata M., Igarashi Y., Kihara A.
Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy.
Molecular Vision 2010 Nov 18;16:2438-2445.

Fujiwara K., Kitatani K., Yazama H., Umehara H., Kikuchi M., Igarashi Y., Kitano H., Okazaki T.
Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice.
Int J Clin Oncol 2010 16(2): 133-140.

Ohno Y., Suto S., Yamanakaa M., Mizutani Y., Mitsutake S.,Igarashi Y., Sassa T., Kihara A.
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Proc. Natl. Acad. Sci. USA 2010 107(43): 18439-18444.

Mitsutake S., Suzuki C., Akiyama M., Tsuji K., Yanagi T., Shimizu H., Igarashi Y.
ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation.
J. Dermatol. Sci. 2010 Sep 23. 60(2): 128-129

Mitsutake S., Kumada H., Soga M., Hurue Y., Asanuma F., Nagira M., Deguchi M., Date T., Yokose U., Inagaki Y., Sugiura M., Kohama T., Igarashi Y.
Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell-activation.
Prostaglandins & Other Lipid Mediators 2010 Aug 1. 93(3-4): 109-112.

Nozaki H., Itonori S., Sugita M., Nakamura K., Ohba K., Ohnishi M., Imai K., Igarashi Y., Suzuki A., Kushi Y.
Invariant Vƒ¿14 natural killer T cell activation by edible mushroom acidic glycosphingolipids.
Biol. Pharm. Bull. 2010 33, 580-584.

Nishimura H., Akiyama T., Monobe Y., Matsubara K., Igarashi Y., Abe M., Sugihara T., Sadahira Y.
Expression of Sphingosine-1-phosphate receptor 1 in mantle cell lymphoma.
Modern Pathology 2010 23, 439-449.

Igarashi Y., Kannagi R.
Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression.
J. Biochem. 2010 147(1):3-8.

2009

Ishikawa J., Takada S., Hashizume K., Takagi Y., Hotta M., Masukawa Y., Kitahara T., Mizutani Y., Igarashi Y.
Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids.
J Dermatol Sci 2009 Dec;56(3):216-218.

Ohno Y., Ito A., Ogata R., Hiraga Y., Igarashi Y., Kihara A.
Palmitoylation of the sphingosine 1-phosphate receptor S1P1 is involved in its signaling functions and internalization<.br /> Genes to Cells 2009 Aug;14(8):911-923.

Mizutani Y., Mitsutake S., kihara A., Igarashi Y.
Ceramide biosynthesis in keratinocyte and its role in skin function.
Biochimie. 2009 Jun;91(6):784-790.

Tsuji K., Satoh S., Mitsutake S,, Murakami I., Jeong-Ju Park., Qian Li., Young-Tae Chang., Sung-Kee Chung., Igarashi Y.
Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.
Bioorganic & Medicinal Chemistry Letters. 2009 Mar;19(6):1643-1646.

2008

Akiyama T., Hamazaki S., Monobe Y., Nishimura H., Irei I., Igarashi Y., Sadahira Y.
Sphingosine-1-phosphate receptor 1 is a useful adjunct for distinguishing vascular neoplasms from morphological mimics.
Virchows Archiv. 2008;454(2):217-222.

Hara-Yokoyama M., Terasawa K., Kihara A., Kim J-W., Park S-j., Hirabayashi Y., Igarashi Y., Yanagishita M.
Sphingosine kinase 2 inhibitor accelerates Fas-mediated cell death progression in A20/2J cells.
The Open Bioactive Com. J. 2008;1:22-27.

Sato T., Nagafuku M., Shimizu K., Taira T., Igarashi Y., Inokuchi J-I.
Physiological levels of insulin and IGF-1 synergistically enhance the differentiation of mesenteric adipocytes.
Cell Biol Int. 2008 Nov;32(11):1397-1404.

Sato T., Nihei Y., Nagafuku M., Tagami S., Chin R., Kawamura M., Miyazaki S., Suzuki M., Sugahara S-i., Takahashi Y., Saito A., Igarashi Y., Inokuchi J-I.
Circulating levels of ganglioside GM3 in metabolic syndrome: Apilotstudy.
Obesity Research & Clinical Practice. 2008 Dec;2(4):231-238.

Yamanaka M., Anada Y., Igarashi Y.
A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
BBRC. 2008 Oct 31;375(4):675-679.

Akiyama T., Sadahira Y., Matsubara K., Mori M., Igarashi Y.
Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular andlymphatic endothelial cells.
Journal of Molecular Histology. 2008 Oct;39(5):527-533.

Mizutani Y., Kihara A., Chiba H., Tojo H., Igarashi Y.
Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models.
J. Lipid Res. 2008 Jun 9.

Ikeda M., Kanao Y., Yamanaka M., Sakuraba H., Mizutani., Igarashi Y., Kihara A.
Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.
FEBS Lett. 2008 July 9;582(16):2435-2440.

Shi YX., Yoo HS., Lee YM., Kihara A., Igarashi Y., So HY., Yim YH.
A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
Anal. Biochem. 2008 Sep 1;380(1):35-40.

Tsuji K., Mitsutake S., Yokose U., Sugiura, M., Kohama T., Igarashi Y.
Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes.
FEBS J. 2008 Aug;275(15):3815-3826.

Kihara A., Igarashi Y.
Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
Biochim Biophys Acta. 2008 Sep;1781(9):496-502 Review

Tomiyama T., kaihou S., Ishida M., Nishikawa H., Yamazaki N., Tsuji K., Mitsutake S., Igarashi Y.
The water retention effects and action for atopic dermatitis-like symptoms of ethyl alcohol extracts ( from Tamogi-take mushroom) on animal model of atopic dermatitis.
J. Jpn. Soc. Nutr. Food Sci. 2008;61:21-26.

Kohno T., Igarashi Y.
Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P1.
Gene Cell. 2008 Jul;13(7):747-757.

Kihara A., Sakuraba H., Ikeda M., Denpoh A., Igarashi Y.
Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation.
J. Biol. Chem. 2008;11199-11209.

Ikeda M., Kihara A., Denpoh A., Igarashi Y.
The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.
Mol. Biol. Cell. 2008 May;19(5):1922-1931.

Machida T., Hamaya Y., Izumi S., Hamaya Y., Iizuka K., Igarashi Y., Minami M., Levi R., Hirafuji M
Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1 in Rat Vascular Smooth Muscle Cells.
Journal of Pharmacology And Experimental Therapeutics. 2008 Jan 2;321(1):200-209.

2007

Date T., Mitsutake S., Igarashi Y.
Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60.
In Vitro Cellular &; Developmental Biology - Animal. 2007 Nov-Dec;43(10):321-323.

Mitsutake S., Yokose U., Kato M., Matsuoka I., Yoo LM., Kim TJ., Yoo HS., Fujimoto K., Ando Y., Sugiura M., Kohama T., Igarashi Y.
The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.
Biochem Biophys Res Commun. 2007 Nov 23;363(3):519-524.

Kabayama K., Sato T., Saito K., Loberto N., Prinetti A., Sonnino S., Kinjo M., Igarashi Y., Inokuchi JI.
Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13678-13683.

Iwaki S., Sano T., Takagi T., Osumi M., Kihara A., Igarashi Y.
Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.
J. Biol. Chem. 2007 Sep 28;282(39):28485-28492

Noguchi M., Suzuki T., Kabayama K., Takahashi H., Chiba H., Shiratori M., Abe S., Watanabe A., Satoh M., Hasegawa T., Tagami S., Ishii A., Saito M., Kaneko M., Iseki K., Igarashi Y., Inokuchi J.
GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.
Cancer Science. 2007 Oct;98(10):1625-1632. Epub 2007 Aug 16.

Kumada H., Mitsutake M., Igarashi Y.
Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast cell activation.
Biosci. Biotech. Biochem. 2007 71(10):2581-2584.

Mitsutake M., Igarashi Y.
Transbilayer movement of ceramide in the plasma membrane of live cells.
Biochem Biophys Res Commun. 2007 Aug 3;359(3):622-627.

Kasahara K., Nakayama Y., Kihara A., Matsuda D., Ikeda K., Kuga T., Fukumoto Y., Igarashi Y., Yamaguchi N.
Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.
Exp. Cell Res. 2007 Jul 15;313(12):2651-2666. Epub 2007 May 8.

Anada Y., Igarashi Y., Kihara A.
The immunomodulator FTY720 is phosphorylated and released from platelets.
Eur J Pharm. 2007 Jul 30;568(1-3):106-111.

ŒÜ\—’–õ”VA–ØŒ´Í—Y.
ƒXƒtƒBƒ“ƒSŽ‰Ž¿‚̐¶—Šˆ«‚Æ‘ãŽÓ’²ß
ƒoƒCƒI‚ƃiƒm‚Ì—Z‡II V¶–½‰ÈŠw‚̉ž—p –kŠC“¹‘åŠwCOEŒ¤‹†¬‰Ê•ÒWˆÏˆõ‰ï•Ò, 2007 117-31.

Nodai A., Machida T., Izumi S., Hamaya Y., Kohno T., Igarashi Y., Iizuka K., Minami M., Hirafuji M.
Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.
Life Sci. 2007 Apr 17;80(19):1768-1776. Epub 2007 Feb 20.

Kihara A., Mitsutake S., Mizutani Y., Igarashi Y.
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Prog. Lipid Res. 2007 Mar;46(2):126-144.

Ito K., Anada Y., Tani M., Ikeda M., Sano T., Kihara A., Igarashi Y.
Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.
Biochem Biophys Res Commun. 2007 May 25;357(1):212-217. Epub 2007 Mar 28.

Uemura S., Feng F., Kume M., Yamada K., Kabayama K., Nishimura S.-I., Igarashi Y., Inokuchi JI.
Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers.
Glycobiology. 2007 Jun 17;(6):568-577.

Uemura S., Kihara A., Iwaki S., Inokuchi JI., Igarashi Y.
Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
J Biol Chem. 2007 Mar 23;282(12):8613-8621.

Tani M., Ito M., Igarashi Y.
Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.
Cell Signal. 2007 Feb;19(2):229-237. Epub 2006 Sep 11. Review.

2006

Matsuyuki H., Maeda Y., Yano K., Sugahara K., Chiba K., Kohno T., Igarashi Y.
Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells Toward S1P.
Cell Mol Immunol. 2006 Dec;3(6):429-437.

Jin YX., Yoo HS., Kihara A., Choi CH., Oh S., Moon DC., Igarashi Y., Lee YM.
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
Arch Pharm Res. 2006 Nov;29(11):1049-1054.

Tsuji K., Mitsutake S., Ishikawa J., Takagi Y., Akiyama M., Shimizu H., Tomiyama T., Igarashi Y.
Dietary glucosylceramide improves skin barrier function in hairless mice.
J Dermatol Sci. 2006 Nov;44(2):101-107. Epub 2006 Sep 26.

Kihara A.
The multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics.
Seikagaku. 2006 Aug;78(8):725-737. Japanese.

Œõ•iAŒÜ\—’–õ”V
ƒgƒsƒbƒNƒXFƒZƒ‰ƒ~ƒhƒLƒi[ƒ[‚Ì‹@”\‚Æ‘jŠQÜ‚Ì”­Œ©; A new function and inhibitor of ceramide kinase.
ƒoƒCƒIƒTƒCƒGƒ“ƒX‚ƃCƒ“ƒ_ƒXƒgƒŠ[, 2006 64(9).

Ikeda M., Kihara A., Igarashi Y.
Lipid asymmetry of the eukaryotic plasma membrane: functions and related enzymes.
Biol Pharm Bull. 2006 Aug;29(8):1542-1546. Review.

Mizutani Y., Kihara A., Igarashi Y.
LASS3 is a testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.
Biochem. J. 2006 Sep 15;398(3):531-538.

Hiraga Y., Kihara A., Sano T., Igarashi Y.
Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.
Biochem Biophys Res Commun. 2006 Jun 9;344(3):852-858. Epub 2006 Apr 19.

Noguchi M., Kabayama K., Uemura S., Kang BW., Saito M., Igarashi Y., Inokuchi JI.
Endogenously Produced Ganglioside GM3 Endows Etoposide and Doxorubicin Resistance by Up-regulating Bcl-2 Expression in 3LL Lewis Lung Carcinoma Cells.
Glycobiology. 2006 Jul;16(7):641-650. Epub 2006 Mar 29.

Ohno Y., Kihara A., Sano T., Igarashi Y.
Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.
Biochim Biophys Acta. 2006 Apr;1761(4):474-483. Epub 2006 Apr 7.

Inagaki Y., Mitsutake S., Igarashi Y.
Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein.
Biochem Biophys Res Commun. 2006 Mar 31;343(3):982-987.

Kobayashi N., Nishi T., Hirata T., Kihara A., Sano T., Igarashi Y., Yamaguchi A.
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.
J Lipid Res. 2006 Mar;47(3):614-621.

Uemura S., Kurose T., Suzuki T., Yoshida S., Ito M., Saito M., Horiuchi M., Inagaki F., Igarashi Y., Inokuchi JI.
Substitution of the N-glycan function in glycosyltransferases by specific amino acids: ST3Gal-V as a model enzyme.
Glycobiology. 2006 Mar;16(3) 258-270.

Kihara A., Anada Y., Igarashi Y.
Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization.
J Biol Chem. 2006 Feb 17;281(7):4532-4539.

Tani M., Kihara A., Igarashi Y.
Rescue of cell growth by sphingosine in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis with disruption of lipid microdomain formation.
Biochem J. 2006 Feb 15;394(Pt 1):237-242.

Akao Y., Banno Y., Nakagawa Y., Hasegawa N., Kim TJ., Murate T., Igarashi Y., Nozawa Y.
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
Biochem Biophys Res Commun. 2006 Apr 21;342(4):1284-1290.

Takeda S., Mitsutake S., Tsuji K., Igarashi Y.
Apoptosis Occurs via the Ceramide Recycling Pathway in Human HaCaT Keratinocytes.
J Biochem (Tokyo). 2006 Feb;139(2):255-262.

Kim TJ., Mitsutake S., Igarashi Y.
The interaction between the pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels.
Biochem Biophys Res Commun. 2006 Apr 7;342(2):611-617.

2005

Kim JW., Inagaki Y., Mitsutake S., Maezawa N., Katsumura S., Ryu YW., Park CS., Taniguchi M., Igarashi Y.
Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.
Biochim Biophys Acta. 2005 Dec 30;1738(1-3):82-90.

Mitsutake S., Igarashi Y.
Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor.
J. Biol. Chem. 2005 Dec 9;280(49):40436-40441.

Sano T., Kihara A., Kurotsu F., Iwaki S., Igarashi Y.
Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: Studies in phytosphingosine-resistant mutants.
J Biol Chem. 2005 Nov 4;280(44):36674-36682.

Tani M., Igarashi Y., Ito M.
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.
J Biol Chem. 2005 Nov 4;280(44):36592-36600.

Kihara A., Kurotsu F., Sano T., Iwaki S., Igarashi Y.
Long-chain base kinase Lcb4 is anchored to the membrane through its palmitoylation by Akr1.
Mol. Cell. Biol. 2005 Nov;25(21):9189-9197.

Tani M., Sano T., Ito M., Igarashi Y.
Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.
J Lipid Res. 2005 Nov;46(11):2458-2467.

Kim TJ., Mitsutake S., Kato M., Igarashi Y.
The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.
FEBS Lett. 2005 Aug 15;579(20):4383-4388.

Mizutani Y., Kihara A., Igarashi Y.
Mammalian longevity assurance homolog LASS6 and its related family members regulate synthesis of specific ceramides.
Biochem J. 2005 Aug 15;390(Pt 1):263-271.

Sato T., Zakaria AM., Uemura S., Ishii A., Ohno-Iwashita Y., Igarashi Y., Inokuchi JI.
Role for upregulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
Glycobiology. 2005 Jul;15(7):687-699.

Kariya Y., Kihara A., Ikeda M., Kikuchi F., Nakamura S., Hashimoto S., Choi CH., Lee YM., Igarashi Y.
The sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway, and not S1P, stimulates mitogenesis.
Genes Cells. 2005 Jun;10(6):605-615.

Yabu T., Tomimoto H., Taguchi Y., Yamaoka S., Igarashi Y., Okazaki T.
Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors, and antagonized by sphingosine-1-phosphate.
Blood. 2005 Jul 1;106(1):125-134.

Kim JW., Kim YW., Inagaki Y., Hwang YA., Mitsutake S., Ryu YW., Lee WK., Ha HJ., Park CS., Igarashi Y.
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases.
Bioorg. Med. Chem. 2005 May 16;13(10):3475-3485.

Inagaki Y., Pham TT., Fujiwara Y., Kohno T., Osborne DA., Igarashi Y., Tigyi G., Parrill AL.
Sphingosine-1-phosphate analog recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.
Biochem J. 2005 Jul 1;389(Pt 1):187-195.

Ikeda M., Kihara A., Kariya Y., Lee YM., Igarashi Y.
Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.
Biochem Biophys Res Commun. 2005 Apr 8; 329(2): 474-479.

Koda M., Murate T., Wang S., Ohguchi K., Ikeda M., Tamiya-Koizumi K,. Igarashi Y., Nozawa Y., Banno Y.
Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granurocytic differentiation through up-regulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells.
Biochim Biophys Acta. 2005 Apr 15;1733(2-3):101-110.

Iwaki S., Kihara A., Sano T., Igarashi Y.
Phosphorylation by Pho85 cyclin-dependent kinase acts as a signal for the down-regulation of the yeast sphingoid long-chain base kinase Lcb4 during the stationary phase.
J Biol Chem. 2005 Feb 25;280(8):6520-6527.

Kabayama K., Sato T., Kitamura F., Uemura S., Kang BW., Igarashi Y., Inokuchi JI.
TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3.
Glycobiology. 2005 Jan;15(1):21-29.

2004”NˆÈ‘O‚Í‚±‚¿‚ç